Radial Streaking in the Fundus of the Carrier State of X-Linked Albinism

Computer animation of the morphogenetic model for radial streaking in the fundus of the carrier state of X-linked albinism. Initially, the retinal pigment epithelial subdomains are characterized by a pigment mosaicism due to X-linked lyonization, where pigmented retinal pigment epithelial precursors (orange circles) randomly alternate with unpigmented retinal pigment epithelial precursors (white circles). As development proceeds, retinal pigment epithelial precursors within the central domain follow a spotty clonal growth maintaining their relative central position, while retinal pigment epithelial precursors within the temporal and nasal domains undergo significant anterior-to-posterior migration and radial clonal growth.